Molecular Biophysics faculty are drawn from the departments of Applied Physiology, Biology, Biomedical Engineering, Chemistry and Biochemistry, Mechanical Engineering, and Physics.
Ed Balog, Applied Physiology
Studies of intracellular ion channels known as ryanodine receptors (RyRs). These proteins are the primary efflux pathway for the release of calcium from the sarcoplasmic reticulum.
Bridgette Barry, Chemistry & Biochemistry
Director, Molecular Biophysics Training Program
Biological electron transfer, membrane biophysics, DNS synthesis, peptide maquettes, vibrational spectroscopy, EPR spectroscopy, photosynthesis.
Investigation of the structure, mechanics and function of the pericellular coat and hyaluronan‐protein macromolecular assemblies; the mechanics of phagocytosis using biophysical and nanopatterning tools.
Single molecule spectroscopy, fluorophore design and utilization in materials and biology, laser spectroscopy and dynamics, nanoparticle synthesis and photophysics, biolabeling, superresolution and high‐sensitivity optical microscopy.
Nanoscience: synthesis and study of the properties of nanomaterial of different shapes, nanotechnology: potential use of nanoparticles in: a) nanomedicine: diagnostics and selective photothermal therapy of cancer, b) nanocatalysis: shape dependence in cage effects.
Development and application of cation‐selective fluorescent probes for biophotonics. Study of metal‐ion distribution and subcellular localization in live cells by x‐ray fluorescence microscopy.
JC Gumbart, School of Physics
Molecular dynamics simulations of membrane-protein insertion and function at both the inner and outer bacterial membranes, bacterial cell wall dynamics and growth, nascent-peptide-ribosome interactions.
Analytic and computational approaches in nonequilibrium statistical mechanics to understand the structure and dynamics within and between proteins.
Elucidation of the fundamental chemical and physical principles that govern nucleic acid assembly at multiple scales, from cation‐mediated RNA folding in the ribosome to the organization of DNA in viruses and bacterial cells.
Quantitative understanding of transcription‐factor activated gene expression in eukaryotic cells with emphasis on the role of nucleosome position/energetics and threedimensional organization of the genome in gene regulation. Fluorescence microscopy of live cells and single molecules.
Protein crystallography, enzymology, biophysics, chemical biology and in silico modeling to elucidate the structure, function and mechanism of enzymes that perform hydrolysis reactions in an unusual chemical environment within or at the surface of the lipid bilayer of a cell.
Nael McCarty, Emory School of Medicine, Biology, Chemistry and Biochemistry
Biophysical approaches to understand the structure, function, and regulation of plasma membrane ion channels and receptors.
Development and use of fluorescence microscopy to image intracellular dynamics. Specific systems of interest include the transport of extracellular cargo and nanoparticle‐cell interactions.
Biophysical and biochemical characterization of cellular transition metal trafficking, metalloproteins and metalloproteomes, placing an emphasis on systems relevant to cancer, neurodegenerative disorders, and infectious diseases.
Structure of eukaryotic membrane proteins and membrane protein complexes by electron crystallography.
C. David Sherrill, Chemistry & Biochemistry, Computational Science & Engineering
Quantum mechanical models of electronic structure used to obtain reliable binding energies and substituent effects for non‐covalent interactions in nucleic acids and between protein side‐chains.
Jeffrey Skolnick, Biology, Chemistry & Biochemistry, Computational Science & Engineering
Todd Sulchek, Mechanical Engineering, Bioengineering
Bioengineering and microelectromechanical systems: atomic force microscopy, pathogen adhesion and endocytosis, cell biomechanics, single molecule biophysics, drug delivery and targeting, biosensors.
Mechanism of protein facilitated sRNA regulation of mRNA expression; assembly and stability of RNA structures
Experimental and informatic approaches to determining and characterizing nucleic acid structures, and the forces that govern the structures.
Cheng Zhu, Biomedical Engineering, Bioengineering
Biomechanics of cell adhesion and signaling molecules of the immune system and the vascular systems.